Neutropenic Enterocolitis: Case report and literature review

Typhlitis, is also known as neutropenic enterocolitis, affects the cecum and distal ileum. It was frequently encountered in pediatricpatients who were undergoing treatment for leukemia. Nonetheless, it can affect adult patients, regardless of cause immunosuppression. We report case a 20-year-old patient receiving chemotherapy Osteosarcoma, had 6-day history nausea vomiting, fever sensation, diarrhea, diffuse abdominal pain. Physical examination relevant hemodynamic instability, distended tender abdomen predominantly right iliac fossa. The laboratory workup showed severe neutropenia, thrombocytopenia, electrolyte disturbances. image studies evidenced edema ascending colon cecum. Treatment started with vasopressor support, correction alterations, blood cell platelet transfusion, G-CSF, hydration, broad spectrum antibiotic therapy, initially adequate clinical response. After few days, he presented lower gastrointestinal bleeding which treated by conservative management. In conclusion, typhlitis must be suspected every developing neutropenia reaction to presents symptoms, such nausea, intense